LD50-peso corporal.htm

LD50s for Various Substances (with ratios regarding relative safety/toxicity)

SUSTANCIA	LD50	VIA	ANIMAL	DOSIS HUMANA TIPICA	MARGEN DE SEGURIDAD LD50=DOSES/50KG

LSD	46 mg/Kg	iv	ratónes	0.25 mg o	9200
	16.5 mg/Kg	iv	ratas		3300
	3 mg/Kg	iv	conejos		60
PSILOCIBINA	285 mg/Kg	iv	ratones	12-20 mg o	1187 - 712
	280 mg/Kg	iv	ratas		1166 - 700
	12.5 mg/Kg	iv	conejos		52 - 31
DMT	110 mg/kg	im	ratón	60 mg im	91
DET	28 mg/kg	iv	ratón	60 mg im/po	23
5-MEO-DMT	115 mg/kg	ip	ratón	6 mg p	958
DPT	20 mg/kg	iv	ratón	60 mg po	16
DIPT	26 mg/kg	iv	ratón	30 mg o	43
THC	1270 mg/Kg	o	ratas (m)	20mg o	3175
	730 mg/Kg	o	ratas (h)	20mg o	1825
	105.7 mg/Kg	iv	ratas	5mg(smoked)	1057
	42 mg/Kg	(inhalación)	ratas	5mg(smoked)	420
CAFEINA	127 mg/Kg	o	ratones (macho)	100-200mg o	63 - 31
	137 mg/Kg	o	ratones (hembra)	c	68 - 34
	230 mg/Kg	o	hamster (macho)	c	115 - 57
	249 mg/Kg	o	hamster (female)	c	124 - 62
	355 mg/Kg	o	rata (macho)	c	177 - 88
	247 mg/Kg	o	rata (hembra)	c	123 - 61
	246 mg/Kg	o	conejo (macho) c	123 - 61
	227 mg/Kg	o	conejo (hembra)	c	113 - 56
NICOTINA	230 mg/Kg	o	ratones
	9.5 mg/Kg	ip	ratones	.7mg(smoked)	675
	.3 mg/Kg	iv	ratones	21
ASPIRINA	1100 mg/Kg	o	ratones	325mg o	169
	1500 mg/Kg	o	ratas	230
ACETAMINOPHEN	338 mg/Kg	o	ratones	500mg o	33.8
	500 mg/Kg	ip	ratones	50
VITAMINA A	2570 mg/Kg	o	ratones	10-20mg o	12850 - 6425
	1510 mg/Kg	ip	ratones		7550 - 3775
ESTRICNINA	96 mg/Kg	iv	ratas	.25mg o	192 (relativo a una dosis de LSD)
SUCCINYL CHOLINE	.45 mg/Kg	iv ratones
VX (GAS NERVIOSO)	.0154 mg/Kg	iv	conejos	0 mg	none

Abreviaciones:

iv=intravenoso (inyectado en la vena)
ip=intraperitoneal (inyectado dentro de la cavidad corporal)
im=intramuscular (inyectado dentro de los músculos)
o=oral
p=parenteral (inhalado o esnifado)
mg/Kg=milligramos de droga por kilo de peso corporal
mg=milligramos de droga

Substance Reckoned Safety Ratio (Closest Available Analogy)

Vitamin A	9637	(ratones oral:human oral 15mg)
LSD	4816	(rodents iv:human oral 0.25mg),averaged
5-MeO-DMT	958	(ratones intraperitoneal:human parenteral 6mg)
Psilocybin	641	(rodents iv:human oral 16mg),averaged
THC	420	(ratasinhaled:human smoked 5mg)
Aspirin	199	(rodents oral:human oral 325mg),averaged
DMT	91	(ratones intramuscular:human intramuscular 60mg)
Caffeine	84	(rodents oral:human oral 150mg),averaged
Acetaminophen	34	(ratones oral:human oral 500mg)
Nicotine	21	(ratones iv:human smoked 0.7mg)
VX	(Nerve Gas)	0 (just a hunch)

NOTES:

All LD50's are normalized to milligrams/Kilogram of animal's body weight.

All LD50 data were found in the "The Merck Index, 11th edition".

The "LD50" is the dose of a substance that will kill a selected species of experimental animal 50% of the time.

"Typical Human Dose" info is taken from various sources, including "Burger's Medicinal Chemistry", "Journal of Psychedelic Drugs", "The Merck Manual", "NIOSH Registry of Toxic Effects of Chemical Substances", cigarette packages, No-Doz bottles, etc.

The "Safety Ratio" was fabricated for the purpose of this information file based on notions of relative toxicity expressed in various pharmacology textbooks and in a taped lecture by Andrew Weil MD.

The "Safety Ratio" is based on the dubious assumption that a human has the same LD50 as an experimental animal in relation to body weight. The Typical Human Dose for "recreational" or therapeutic purposes is expressed in milligrams and the number of those doses required to reach the corresponding LD50 for a 50 Kilogram (110 pound) human is computed. The assumption here is that the margin of safety for a drug is proportional to the number of typical doses a person would have to take in order to have a 50% chance of dropping dead were they a giant rodent. According to this reasoning, the higher the "Safety Ratio" is, the less toxic the drug is at normal dosages.

One might well argue that it is of questionable utility to compare toxic responses between various species using different routes of administration. Needless to say, many rodents have died for our sins.

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It was later pointed out that what is called above a "safety ratio" is roughly equivalent to the pharmacological measure known as the "Therapeutic Index". The therapeutic index is a measure of the toxicity of a drug relative to it's usual therapeutic dose.

The NIOSH Registry of Toxic Effects of Chemical Substances also lists most published LD50 measurements, but does so uncritically. It's quite useful as a point of reference.