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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

LSD Accelerates Brain Rhythms and Increases Neural Complexity

Psiconáutica Editorial Team · October 8, 2026 In briefA magnetoencephalography (MEG) reanalysis of 17 volunteers indicates that LSD accelerates the brain’s alpha and beta rhythms,...

Canada Launches New Controlled Substances Regulations for Psilocybin

Psiconáutica Editorial Team · October 8, 2026 In briefOn October 1, 2026, Canada’s new Controlled Substances Regulations went into effect, consolidating several previous rules into...

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Miguel Ángel Velasco: Poetry and Visionary Trance

Miguel Ángel Velasco has passed away. Beyond being a friend and accomplice in certain visionary pursuits, he was one of the finest poets in the Spanish language in recent decades. By José Carlos Aguirre.

Hofmann, Ololiuqui, and the Chemistry of Psychedelics

With this installment* we say goodbye to the series of articles by—and about—Albert Hofmann. The good doctor explains the foundations of using entheogens in psychotherapy, a currently fashionable topic but one that was very common in medical practice during the 1950s and early 1960s, before these drugs were banned. At the end he reaches the conclusion later developed in the psychotherapeutic approaches of Humphrey Osmond, Abram Hoffer, and Stanislav Grof, among others.

LSD, la medicina del doctor Albert Hofmann

Peyote (Lophophora williamsii): The Mescaline Cactus

Peyote is a small, spineless, carrot-shaped cactus that grows in Mexico, Texas, and New Mexico—on both sides of the Rio Grande and further south in regions like Zacatecas and Tamaulipas—thriving in limestone deserts and river valleys under the shade of shrubs that protect it from the harsh sun.

 

The History of Ketamine: From the Operating Room to Psychiatry

From its 1962 synthesis as an anesthetic to the FDA-approved esketamine for treatment-resistant depression, we explore the history of ketamine.

The Medicinal Side of Power Plants

An ethnobotanical journey through the traditional medicinal uses of psychoactive plants and fungi, with critical analysis and harm reduction.

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