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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Heroin and Heartbreak: Eduardo Hidalgo’s Stigma-Free Memoir

Eduardo Hidalgo releases a memoir through Autsaider Cómics detailing nearly forty years of heroin use. A guilt-free testimony that challenges the only narrative society accepts about this substance.

MDMA comedown: what a survey of 497 people found

In a cross-sectional survey of 497 people with MDMA experience, 74.5% reported negative aftereffects at least once. This self-reported sample does not establish causality, represent all users or demonstrate that supplements or antidepressants are effective for managing comedowns.

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How to Differentiate Between LSD and 25i-NBOMe

A guide to distinguishing LSD from 25i-NBOMe: key identifiers and harm reduction tips to avoid dangerous mix-ups.

Psychedelic Psychotherapy Examined: What Does Evidence Say?

We critically examine clinical trials of psilocybin and LSD in terminal illness: modest outcomes contrasting with euphoric media headlines.

Harm Reduction: Between Scientific Evidence and Political Rhetoric

A critical analysis of how public health harm reduction strategies face sensationalist headlines, statistical ignorance, and polarization.

Ketamine: Between Anesthesia and Neuronal Regeneration

We explore the clinical profile of ketamine, from its safety in surgery to its emerging role in treatment-resistant depression and addiction.

MDMA and Pain Relief: Science, Risk, and Perspective

We explore evidence for the analgesic properties of MDMA, analyzing its serotonergic mechanism, historical clinical cases, and harm reduction.

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