Eduardo Hidalgo releases a memoir through Autsaider Cómics detailing nearly forty years of heroin use. A guilt-free testimony that challenges the only narrative society accepts about this substance.

In a cross-sectional survey of 497 people with MDMA experience, 74.5% reported negative aftereffects at least once. This self-reported sample does not establish causality, represent all users or demonstrate that supplements or antidepressants are effective for managing comedowns.

We explore how MDMA influences the processing of negative emotions, social rejection responses, and feelings of self-compassion.

Antonio Escohotado discusses cannabis, the boundary between use and abuse, home growing, and his political critique of prohibition.

Part three of the series: what sustainable drug use proposes and what legal drug regulation could look like instead of prohibition.

Wild lettuce (Lactuca virosa) and its latex, lactucarium, once promised dreams and mild sedation. We review the history, science, and risks.

From Amazonian brews to Szára and Strassman: what we know about DMT, why the body produces it, and where data ends and mythology begins.