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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Heroin and Heartbreak: Eduardo Hidalgo’s Stigma-Free Memoir

Eduardo Hidalgo releases a memoir through Autsaider Cómics detailing nearly forty years of heroin use. A guilt-free testimony that challenges the only narrative society accepts about this substance.

MDMA comedown: what a survey of 497 people found

In a cross-sectional survey of 497 people with MDMA experience, 74.5% reported negative aftereffects at least once. This self-reported sample does not establish causality, represent all users or demonstrate that supplements or antidepressants are effective for managing comedowns.

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Getting High on Batteries: Anatomy of an Urban Legend

In 2009, an alarm was raised: teenagers were allegedly snorting battery acid. We examine the origin of this hoax and why it doesn't hold up.

Cannabis and Psychosis: What the Evidence Says

Can cannabis cause psychosis? We review acute effects, epidemiological data, and the limits of causality with a critical, harm-reduction lens.

Adrenochrome: Anatomy of a Hoax Between QAnon and the Pandemic

What is real about adrenochrome, how QAnon and Pizzagate amplified it during COVID-19, and why we must examine conspiratorial folklore critically.

The History of Ketamine: From the Operating Room to Psychiatry

From its 1962 synthesis as an anesthetic to the FDA-approved esketamine for treatment-resistant depression, we explore the history of ketamine.

Tramadol: The Atypical Opioid That Doesn’t Act Like One

What is tramadol, how does it affect opioids, serotonin, and norepinephrine, and why its interactions and seizure risk demand caution.

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