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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...

Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...

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Ibogaine Legality and Clinics Worldwide: What We Know

Ibogaine shows promise in treating addiction and trauma. We review its legal status by country, the state of clinics, and associated cardiac risks.

‘Peyote, San Pedro, and Mescaline: Mind-Altering Cacti’

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Since remote antiquity, indigenous peoples in the Americas consumed hallucinogenic plants, attributing to them the power to heal, commune with deities, and access diverse powers. The Americas are home to the greatest diversity of plants containing psychoactive principles. These plants contain chemical substances capable of giving rise to altered states of consciousness and sensory changes.

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Salvia divinorum Effects: Why They Are So Intense and Brief

Salvinorin A activates the kappa-opioid receptor, which is why the effects of Salvia divinorum are so intense and last only a few minutes.

The Amsterdam Hash Marihuana & Hemp Museum: Forgotten History

A tour through Amsterdam's Hash Marihuana & Hemp Museum and the long industrial, artistic, and medicinal history erased by modern prohibition.

“Albert Hofmann: Chance, Fate, and the Origin of LSD”

We conclude Hofmann's autobiography written by the good doctor to be read at his funeral, a summary of his life and a beautiful farewell to his family, friends, psychonauts, and drug enthusiasts alike. Following that, the article "LSD: Completely Personal" delves deeper into his life and the history of LSD.

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