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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Why Marijuana Is Illegal: The History of Prohibition

From mandatory crop to contraband plant: an objective historical account of how cannabis was criminalized in the United States and the corporate interests involved.
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Psychonautics

“Mystery Cults of Rome: Attis, Isis, and Mithras”

Given the relationship between Romans and their gods—built on a transactional faith where worship secured protection—skepticism and abandonment of the traditional Roman creed took deep root in society between the 1st and 3rd centuries.

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Psychonautics

Kanna (Sceletium tortuosum): The Mild Sedative of the San and Khoi

Kanna (Sceletium tortuosum) is a South African succulent used by the San and Khoikhoi. We examine its chemistry, subjective effects, and safety limits.
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Fuerteventura and Psychedelic Therapy: From Enthusiasm to Caution

An international gathering in Fuerteventura brought together experts in psychedelic-assisted therapy. We explore its promises, limits, and the need for caution.
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Psychonautics

Ibogaine Legality and Clinics Worldwide: What We Know

Ibogaine shows promise in treating addiction and trauma. We review its legal status by country, the state of clinics, and associated cardiac risks.
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