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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Sustainable Hedonism (Part 7): Safer Drugs and Destigmatizing Users

Concluding the Sustainable Hedonism series: redirecting science toward safer consumption and normalizing the social status of people who use drugs.
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Psychonautics

Dalí: Exploring Alternate States Without Substances

Surrealism, Freud, and the paranoiac-critical method: how Dalí bypassed reason without entheogens and why Leary hailed him as the LSD painter without LSD.
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Psychonautics

MDMA and Social Bonding: Selective Empathy, Generosity, and Context

We explore how MDMA modulates emotional perception and fosters prosocial behaviors like generosity, all within a harm reduction framework.
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Psychonautics

Opium and Coffee: The History of Smart Drugs in Europe

A journey through opium and coffee as substances that shaped European creativity. Includes historical analysis, harm reduction, and cultural context.
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Psychonautics

Legal Biases in Drug Research: Between Fear and Science

An analysis of how legal frameworks shape scientific studies on cannabis, exploring research biases, police stress, and the need for critical reading.
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