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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Heroin and Heartbreak: Eduardo Hidalgo’s Stigma-Free Memoir

Eduardo Hidalgo releases a memoir through Autsaider Cómics detailing nearly forty years of heroin use. A guilt-free testimony that challenges the only narrative society accepts about this substance.

MDMA comedown: what a survey of 497 people found

In a cross-sectional survey of 497 people with MDMA experience, 74.5% reported negative aftereffects at least once. This self-reported sample does not establish causality, represent all users or demonstrate that supplements or antidepressants are effective for managing comedowns.

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MDMA and Social Bonding: Selective Empathy, Generosity, and Context

We explore how MDMA modulates emotional perception and fosters prosocial behaviors like generosity, all within a harm reduction framework.

Ergot: From St. Anthony’s Fire to Witchcraft

In the previous installment we began a brief history of ergot, the fungus from which drugs as well known as LSD and Hydergine, created by Albert Hofmann, are derived. Its importance is not limited to the good doctor’s work: its bond with humankind began in antiquity.

Dalí: Exploring Alternate States Without Substances

Surrealism, Freud, and the paranoiac-critical method: how Dalí bypassed reason without entheogens and why Leary hailed him as the LSD painter without LSD.

Testosterone: Between Biology, Power, and the Construction of Gender

Testosterone is far more than a bodybuilding supplement or a binary hormone. This article explores how it shapes not only human physiology, but also our perceptions of power, masculinity, and sexual identity in contemporary society.

‘Opium as a “Smart Drug”: History and Critical Analysis’

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When we speak of smart drugs, almost everyone thinks of modern pharmaceuticals that act on our brain to boost performance. Yet before the pharmacological era of the late 19th century, opium poppy juice was the intellectual substance par excellence, taken when lucidity, calm, and emotional stability were sought. Opium was seen as an agent that stilled instinctive impulses while leaving the intellect clear and free.

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