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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...

Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...

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Mapping the Invisible: Science and Subjectivity in Drug Effects

Discover how psychopharmacology quantifies subjective experiences. We analyze validated scales like ARCI, HRS, and VESSPA to understand differences.

Alexander Shulgin: The Chemist Who Mapped the Mind

A portrait of Alexander Shulgin (1925–2014), the chemist who characterized MDMA and created 2C-B, and the legacy he left in psychedelic research.

‘How LSD Originated: Hofmann and the Years Before the Discovery’

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We continue presenting writings by Albert Hofmann. The article that opens this installment recounts the origins of the discovery of LSD. Its title is "How LSD originated"1 and it was published around the date the first German edition of LSD - Mein Sorgenkind was released. Those familiar with Hofmann's autobiographical book will surely find it familiar because it forms part of the material used in writing it.

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Sustainable Drugophilia: Regulating Drugs Instead of Prohibition

Part three of the series: what sustainable drug use proposes and what legal drug regulation could look like instead of prohibition.

Aspirin or White Willow? The Truth About Common Painkillers

Who hasn't taken an aspirin? For a headache, the flu, or a common cold, we have all swallowed a pill or sipped an effervescent aspirin at some point. This substance is so everyday and ubiquitous that few know its true name, and almost no one considers it a drug.

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