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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Turkestan Mint: The Forgotten Sedative of Central Asia

Lagochilus inebrians, or Turkestan mint, is a sedative shrub from Central Asia. History, chemistry, traditional uses, and a critical analysis.
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Psychonautics

Hofmann, Huxley, and Jünger: Literature and Psychedelia

We conclude the essay "LSD – Completely Personal"*, begun three months ago. Hofmann recounts his ties with Aldous Huxley and Ernst Jünger, focusing on their shared psychedelic explorations, preceded by brief biographical portraits of both authors.

LSD, Doctor Albert Hofmann's Medicine

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Psychonautics

Psychedelic Visions and the Brain: Beyond Huxley

Where do visions from ayahuasca or LSD originate? We examine the reducing valve hypothesis, the 5-HT2A receptor, and neuroimaging findings.
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Psychonautics

Adrenochrome: Osmond and Hoffer’s Self-Experiments

What did Osmond and Hoffer find when they self-administered adrenochrome in the 1950s, and why did they link it to schizophrenia? A critical review.
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Psychonautics

Toxicomania: The Substance or the Temperament?

Antonio Escohotado's historical analysis of addiction: examining the origins of toxicomania, prohibition, pharmacology, and human character.
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