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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Salvia divinorum Effects: Why They Are So Intense and Brief

Salvinorin A activates the kappa-opioid receptor, which is why the effects of Salvia divinorum are so intense and last only a few minutes.
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Psychonautics

Gecko Turner: Afromeño Soul, Remixes, and Creativity

An interview with the musician behind the unique sound dubbed "afromeño soul."

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Psychonautics

“Peter Tosh: A Guitar as a Rifle Against Babylon”

At the last High Times Cannabis Cup, there was one figure whom virtually every event revolved around, directly or indirectly: Winston Hubert McIntosh, better known as Peter Tosh (10/19/1944 – 9/11/1987).

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Psychonautics

Ketamine: Between Anesthesia and Neuronal Regeneration

We explore the clinical profile of ketamine, from its safety in surgery to its emerging role in treatment-resistant depression and addiction.
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Psychonautics

Ecstasy Cut with Heroin: Anatomy of an Urban Legend

Only three documented reports exist worldwide of heroin in ecstasy pills. We examine the evidence and why heavy sedation stems from MDMA itself.
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