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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Heroin and Heartbreak: Eduardo Hidalgo’s Stigma-Free Memoir

Eduardo Hidalgo releases a memoir through Autsaider Cómics detailing nearly forty years of heroin use. A guilt-free testimony that challenges the only narrative society accepts about this substance.

MDMA comedown: what a survey of 497 people found

In a cross-sectional survey of 497 people with MDMA experience, 74.5% reported negative aftereffects at least once. This self-reported sample does not establish causality, represent all users or demonstrate that supplements or antidepressants are effective for managing comedowns.

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Cannabis Addiction: Is It in the Plant or the Person?

Use, abuse, and dependence do not mean the same thing. We examine why cannabis issues usually stem from the user and their context, not the plant itself.

Hofmann, Huxley, and Jünger: Literature and Psychedelia

We conclude the essay "LSD – Completely Personal"*, begun three months ago. Hofmann recounts his ties with Aldous Huxley and Ernst Jünger, focusing on their shared psychedelic explorations, preceded by brief biographical portraits of both authors.

LSD, Doctor Albert Hofmann's Medicine

LSD Temporary Tattoos: Anatomy of an Urban Legend

The myth of LSD-laced temporary tattoos targeting children has circulated for decades. We unpack its origin, why it is false, and what it reveals about fear.

Von Bibra and the First Modern Book on Drugs (1855)

We continue our look at the work of Baron von Bibra, one of the first authors to publish a treatise on drugs. Read part one.

 

Tramadol: The Atypical Opioid That Doesn’t Act Like One

What is tramadol, how does it affect opioids, serotonin, and norepinephrine, and why its interactions and seizure risk demand caution.

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