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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...

Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...

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“Where Cannabis Comes From: The Equatorial African Trail”

Every grower of psychoactive cannabis has wondered at some point where the commercial strains grown today actually originate.

Testosterone: Between Biology, Power, and the Construction of Gender

Testosterone is far more than a bodybuilding supplement or a binary hormone. This article explores how it shapes not only human physiology, but also our perceptions of power, masculinity, and sexual identity in contemporary society.

Long-Term Effects of Ritual Ayahuasca Use: Science and Harm Reduction

A rigorous analysis of the lasting neuropsychological effects of ritual ayahuasca use, featuring a critical review of longitudinal studies.

Fentanyl: Lethal Potency, Medical Paradox, and Harm Reduction

An analysis of fentanyl, an extremely potent synthetic opioid. We cover its therapeutic use, severe overdose risks, and strict harm reduction guidelines.

Drugs and Literature: Creation in Altered States

From romantic opium eaters to the French Decadents and the Beat Generation: how psychoactive substances influenced modern Western literature.

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