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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...

Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...

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‘Opium as a “Smart Drug”: History and Critical Analysis’

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When we speak of smart drugs, almost everyone thinks of modern pharmaceuticals that act on our brain to boost performance. Yet before the pharmacological era of the late 19th century, opium poppy juice was the intellectual substance par excellence, taken when lucidity, calm, and emotional stability were sought. Opium was seen as an agent that stilled instinctive impulses while leaving the intellect clear and free.

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Salvinorin A: The Most Potent Natural Psychedelic and the Kappa Receptor

Salvinorin A, the main compound in Salvia divinorum, is the most potent natural psychedelic. How it acts on the kappa opioid receptor and its risks.

Understanding Iboga: The African Shrub and Ibogaine Alkaloid

Iboga is an African shrub containing ibogaine, an alkaloid studied for addiction treatment that carries significant cardiac risks.

Ernst von Bibra, the Baron Who Cataloged the World’s Drugs

In the previous two installments, we explored the significance of Ernst von Bibra. Here, we delve into his biography and introduce his work. Read part one. Read part two.

Drugs and Literature: Creation in Altered States

From romantic opium eaters to the French Decadents and the Beat Generation: how psychoactive substances influenced modern Western literature.

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