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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Heroin and Heartbreak: Eduardo Hidalgo’s Stigma-Free Memoir

Eduardo Hidalgo releases a memoir through Autsaider Cómics detailing nearly forty years of heroin use. A guilt-free testimony that challenges the only narrative society accepts about this substance.

MDMA comedown: what a survey of 497 people found

In a cross-sectional survey of 497 people with MDMA experience, 74.5% reported negative aftereffects at least once. This self-reported sample does not establish causality, represent all users or demonstrate that supplements or antidepressants are effective for managing comedowns.

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Yohimbe and Yohimbine: The Aphrodisiac Science Examined

This tree, native to West Africa (Cameroon, Equatorial Guinea, Congo, etc.), is now cultivated in several African countries to satisfy the vast global demand for yohimbe bark and its derivatives, particularly herbal yohimbe extract and pure yohimbine hydrochloride.

Testosterone: Between Biology, Power, and the Construction of Gender

Testosterone is far more than a bodybuilding supplement or a binary hormone. This article explores how it shapes not only human physiology, but also our perceptions of power, masculinity, and sexual identity in contemporary society.

LSD: Acute Effects, Pharmacological Profile, and Harm Reduction

An in-depth analysis of the first modern pharmacological LSD trial: subjective effect profiles, duration, lab safety, and comparison with other psychedelics.

San Pedro (Trichocereus): Mescaline from Andean Cacti

San Pedro cactus (Trichocereus) contains mescaline. We examine its cultural background, highly variable potency, and why caution is essential.

Piracetam: The Origin of Smart Drugs

Piracetam is the standard nootropic, the one we might consider the father of smart drugs. It was first synthesized in 1964 by the team led by Corneliu Giurgea at the Belgian pharmaceutical company UCB (Union Chimique Belge), which was founded in 1928 and specialized in, among other things, medications for the nervous system.

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