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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Crack and Freebase Cocaine (Part II): Risks and Harm Reduction

Continuation of the article on freebase cocaine. Read part 1.

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Psychonautics

Hofmann, Huxley, and Jünger: Literature and Psychedelia

We conclude the essay "LSD – Completely Personal"*, begun three months ago. Hofmann recounts his ties with Aldous Huxley and Ernst Jünger, focusing on their shared psychedelic explorations, preceded by brief biographical portraits of both authors.

LSD, Doctor Albert Hofmann's Medicine

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Psychonautics

Ketamine: Between Anesthesia and Neuronal Regeneration

We explore the clinical profile of ketamine, from its safety in surgery to its emerging role in treatment-resistant depression and addiction.
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Psychonautics

‘How LSD Originated: Hofmann and the Years Before the Discovery’

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We continue presenting writings by Albert Hofmann. The article that opens this installment recounts the origins of the discovery of LSD. Its title is "How LSD originated"1 and it was published around the date the first German edition of LSD - Mein Sorgenkind was released. Those familiar with Hofmann's autobiographical book will surely find it familiar because it forms part of the material used in writing it.

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Psychonautics

Tampodka: Anatomy of a Summer Drug Hoax

What lies behind "tampodka"—the supposed vodka-soaked tampon trend among teens? We break down why it’s a myth and what the evidence actually says.
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