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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

DESOXY: The Shulgin Account of Emotional Blunting

We revisit Ann Shulgin’s experience with DESOXY: a rare case of affective flattening and cold detachment, viewed through a harm reduction lens.
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Psychonautics

We Are Standard: Danceable Pop, London, and the Cannabis Question

Basque band We Are Standard on recording with Andy Gill and Arthur Baker, and a critical look at the myth linking cannabis to musical creativity.
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Psychonautics

Hofmann and Huxley: LSD Between Serendipity and Vision

Albert Hofmann recounts the discovery of LSD and his personal friendship with Aldous Huxley, examined through historical context and critical reflection.
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Psychonautics

Drugs and Literature: Creation in Altered States

From romantic opium eaters to the French Decadents and the Beat Generation: how psychoactive substances influenced modern Western literature.
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Psychonautics

“Alexander Shulgin: The Chemist Who Mapped the Mind”

"A profile of Alexander Shulgin (1925–2014), the chemist who characterized MDMA and created 2C-B, and his enduring mark on psychedelic research."
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