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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Heroin and Heartbreak: Eduardo Hidalgo’s Stigma-Free Memoir

Eduardo Hidalgo releases a memoir through Autsaider Cómics detailing nearly forty years of heroin use. A guilt-free testimony that challenges the only narrative society accepts about this substance.

MDMA comedown: what a survey of 497 people found

In a cross-sectional survey of 497 people with MDMA experience, 74.5% reported negative aftereffects at least once. This self-reported sample does not establish causality, represent all users or demonstrate that supplements or antidepressants are effective for managing comedowns.

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Cannabis and Emotional Distress: When It Becomes the Only Way Out

Cannabis can soothe the sting of life’s setbacks, but relying on it as your sole coping mechanism comes at a cost. We break it down.

MDMA, Empathy, and Compassion: Does It Transform Social Behavior?

We explore how MDMA influences the processing of negative emotions, social rejection responses, and feelings of self-compassion.

Piracetam: The Origin of Smart Drugs

Piracetam is the standard nootropic, the one we might consider the father of smart drugs. It was first synthesized in 1964 by the team led by Corneliu Giurgea at the Belgian pharmaceutical company UCB (Union Chimique Belge), which was founded in 1928 and specialized in, among other things, medications for the nervous system.

Drugs and Literature: Creation in Altered States

From romantic opium eaters to the French Decadents and the Beat Generation: how psychoactive substances influenced modern Western literature.

“Cocaine: Pharmacology, Risks, and Myths of a Stimulant”

Article by Antonio Escohotado. Cocaine is a tropane, structurally related to the alkaloids of hallucinogenic Solanaceae (belladonna, henbane, daturas, mandrake, etc.), though vastly different in its physiological and psychological action.

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