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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Heroin and Heartbreak: Eduardo Hidalgo’s Stigma-Free Memoir

Eduardo Hidalgo releases a memoir through Autsaider Cómics detailing nearly forty years of heroin use. A guilt-free testimony that challenges the only narrative society accepts about this substance.

MDMA comedown: what a survey of 497 people found

In a cross-sectional survey of 497 people with MDMA experience, 74.5% reported negative aftereffects at least once. This self-reported sample does not establish causality, represent all users or demonstrate that supplements or antidepressants are effective for managing comedowns.

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Drugs and Literature: Creation in Altered States

From romantic opium eaters to the French Decadents and the Beat Generation: how psychoactive substances influenced modern Western literature.

Yohimbe and Yohimbine: The Aphrodisiac Science Examined

This tree, native to West Africa (Cameroon, Equatorial Guinea, Congo, etc.), is now cultivated in several African countries to satisfy the vast global demand for yohimbe bark and its derivatives, particularly herbal yohimbe extract and pure yohimbine hydrochloride.

Amphetamines: History, Pharmacology, and Risks of a Stimulant

Synthetic derivatives of ephedrine, these drugs appeared in US pharmacies around 1930 as a way to keep patients awake after sedative overdoses. Shortly after, they were launched as inhalers for colds and nasal congestion, later as pills for motion sickness and obesity, and finally as antidepressants. Following amphetamine itself (Benzedrine, Sympatina, Profamina, Centramina, etc.), its isomer dexamphetamine (Dexedrine) appeared, and in 1938, methamphetamine (Methedrine).

Escohotado and Jack Herer: The Emperor Wears No Clothes

Jack Herer left us on April 15 of this year. We believe it is a fitting time to link to this article about him, written by Antonio Escohotado as an introduction to the Spanish edition of the book The Emperor Wears No Clothes.

Harm Reduction: Between Scientific Evidence and Political Rhetoric

A critical analysis of how public health harm reduction strategies face sensationalist headlines, statistical ignorance, and polarization.

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