Eduardo Hidalgo releases a memoir through Autsaider Cómics detailing nearly forty years of heroin use. A guilt-free testimony that challenges the only narrative society accepts about this substance.

In a cross-sectional survey of 497 people with MDMA experience, 74.5% reported negative aftereffects at least once. This self-reported sample does not establish causality, represent all users or demonstrate that supplements or antidepressants are effective for managing comedowns.

We continue the article begun in our previous installment. Hofmann now describes the properties of the most well-known entheogens of the 1950s—referred to as "psychotomimetics" or "hallucinogens" at the time—among which LSD is counted.

LSD, the medicine of Dr. Albert Hofmann

We explore evidence for the analgesic properties of MDMA, analyzing its serotonergic mechanism, historical clinical cases, and harm reduction.

'

When we speak of smart drugs, almost everyone thinks of modern pharmaceuticals that act on our brain to boost performance. Yet before the pharmacological era of the late 19th century, opium poppy juice was the intellectual substance par excellence, taken when lucidity, calm, and emotional stability were sought. Opium was seen as an agent that stilled instinctive impulses while leaving the intellect clear and free.

'

Biography of Alexander Shulgin, one of the most prolific figures in psychopharmacology, exploring his early life, the placebo event, and his mescaline epiphany.

What is tramadol, how does it affect opioids, serotonin, and norepinephrine, and why its interactions and seizure risk demand caution.