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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

LSD Accelerates Brain Rhythms and Increases Neural Complexity

Psiconáutica Editorial Team · October 8, 2026 In briefA magnetoencephalography (MEG) reanalysis of 17 volunteers indicates that LSD accelerates the brain’s alpha and beta rhythms,...

Canada Launches New Controlled Substances Regulations for Psilocybin

Psiconáutica Editorial Team · October 8, 2026 In briefOn October 1, 2026, Canada’s new Controlled Substances Regulations went into effect, consolidating several previous rules into...

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The Medicinal Side of Five Psychoactive Plants

Mandrake, kratom, opium, yohimbe, and harmel: we review the traditional medicinal uses of five psychoactive plants with critical caution.

The Truth About Smoking Toothpaste: Myths, Fluoride, and Science

Can smoking toothpaste get you high? Far from being a recreational drug, this habit poses a serious toxicological risk. Eduardo Hidalgo debunks urban legends about toothpaste-induced hallucinations and warns of the dangers of fluoride poisoning, urging readers to prioritize dental health instead.

Escohotado: TV Fame, Trials, and Pharmacological Reason

The biography of Antonio Escohotado, the pioneer of pharmacological enlightenment, continues.

‘How LSD Originated: Hofmann and the Years Before the Discovery’

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We continue presenting writings by Albert Hofmann. The article that opens this installment recounts the origins of the discovery of LSD. Its title is "How LSD originated"1 and it was published around the date the first German edition of LSD - Mein Sorgenkind was released. Those familiar with Hofmann's autobiographical book will surely find it familiar because it forms part of the material used in writing it.

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How Anxiety Works: The Fear That Anticipates

Anxiety as an anticipatory emotion, how it distorts attention, memory, and interpretation, and why excessive activation limits our lives.

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