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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Psilocybin and Methamphetamine: How Brain Networks Reorganize

Psiconáutica Editorial Team · October 9, 2026 In briefA functional magnetic resonance imaging (fMRI) study compares the brains of people with methamphetamine use disorder before...

Common Drug Causes False-Positive MDMA Urine Test

Psiconáutica Editorial Team · October 9, 2026 In briefThree patients admitted in Algiers tested positive for MDMA on a rapid urine screen despite no consumption;...

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Ibogaine Legality and Clinics Worldwide: What We Know

Ibogaine shows promise in treating addiction and trauma. We review its legal status by country, the state of clinics, and associated cardiac risks.

Ergot: From St. Anthony’s Fire to Witchcraft

In the previous installment we began a brief history of ergot, the fungus from which drugs as well known as LSD and Hydergine, created by Albert Hofmann, are derived. Its importance is not limited to the good doctor’s work: its bond with humankind began in antiquity.

Cannabis and Creativity: Concepts, Dopamine, and Open Minds

How cannabis and creativity relate: divergent thinking, the dopamine-serotonin balance, and over-inclusion, with critical nuance.

Hofmann and LSD: Chemistry, Potency, and Toxicity

We continue the article begun in our previous installment. Hofmann now describes the properties of the most well-known entheogens of the 1950s—referred to as "psychotomimetics" or "hallucinogens" at the time—among which LSD is counted.

LSD, the medicine of Dr. Albert Hofmann

Hofmann and Psilocybin: From Teonanácatl to the Test Tube

A new installment from the original writings of the discoverer of LSD.

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