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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin and Methamphetamine: How Brain Networks Reorganize

Psiconáutica Editorial Team · October 9, 2026 In briefA functional magnetic resonance imaging (fMRI) study compares the brains of people with methamphetamine use disorder before...
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Common Drug Causes False-Positive MDMA Urine Test

Psiconáutica Editorial Team · October 9, 2026 In briefThree patients admitted in Algiers tested positive for MDMA on a rapid urine screen despite no consumption;...
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Psychonautics

Hofmann and LSD: Chemistry, Potency, and Toxicity

We continue the article begun in our previous installment. Hofmann now describes the properties of the most well-known entheogens of the 1950s—referred to as "psychotomimetics" or "hallucinogens" at the time—among which LSD is counted.

LSD, the medicine of Dr. Albert Hofmann

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Psychonautics

MDMA-Assisted Psychotherapy: From Merck Patent to PTSD Treatment

A look at the history of MDMA as a clinical tool and the evidence regarding its use in treating post-traumatic stress, with a critical reading.
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Psychonautics

Adrenochrome: Osmond and Hoffer’s Self-Experiments

What did Osmond and Hoffer find when they self-administered adrenochrome in the 1950s, and why did they link it to schizophrenia? A critical review.
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Psychonautics

Wild Psychoactive Plants of the Iberian Peninsula (Part 1)

A botanical and critical overview of Iberian wild psychoactive plants: ephedra, opium poppy, wild lettuce, Syrian rue, and khat, with safety warnings.
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Psychonautics

Cannabis and Emotions: Learning to Read Your Own Responses

How cannabis might modulate emotional processing, cortisol, and memory, according to psychology, and why these findings should be read with caution.
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