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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Esketamine (Spravato): The Approved Antidepressant and How It Works

Esketamine (Spravato) is a nasal spray approved for treatment-resistant depression. We explore its NMDA receptor mechanism, evidence, and risks.
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Psychonautics

Absinthe: Between the Green Fairy Myth and Chemical Reality

A sober analysis of absinthe, debunking urban legends and explaining its actual composition versus the effects promised by popular culture.
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Psychonautics

Escohotado on Cannabis: Use, Abuse, and Prohibition

Antonio Escohotado discusses cannabis, the boundary between use and abuse, home growing, and his political critique of prohibition.
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Psychonautics

Sustainable Hedonism (Part 7): Safer Drugs and Destigmatizing Users

Concluding the Sustainable Hedonism series: redirecting science toward safer consumption and normalizing the social status of people who use drugs.
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Psychonautics

Ketamine: Between Anesthesia and Neuronal Regeneration

We explore the clinical profile of ketamine, from its safety in surgery to its emerging role in treatment-resistant depression and addiction.
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