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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

When Crack Replaces Heroin in Madrid

Why freebase has cornered heroin in Madrid’s toughest drug market—economic factors, market shifts, and a harm reduction perspective.
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Psychonautics

LSD and Music: Science, Perception, and Harm Reduction

A scientific review of how LSD amplifies emotional responses to music, actual pharmacokinetics, fMRI imaging studies, and clinical safety considerations.
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Psychonautics

Blue Lotus: Egyptian Myth, Alkaloids, and Psychoactive Legend

What lies behind the blue lotus: the confusion with Tintin, the botany of Nymphaea caerulea and Nelumbo nucifera, their alkaloids, and psychoactive fame.
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Psychonautics

Esketamine (Spravato): The Approved Antidepressant and How It Works

Esketamine (Spravato) is a nasal spray approved for treatment-resistant depression. We explore its NMDA receptor mechanism, evidence, and risks.
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Psychonautics

Kanna (Sceletium tortuosum): The Mild Sedative of the San and Khoi

Kanna (Sceletium tortuosum) is a South African succulent used by the San and Khoikhoi. We examine its chemistry, subjective effects, and safety limits.
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