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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Crack and Freebase Cocaine (Part II): Risks and Harm Reduction

Continuation of the article on freebase cocaine. Read part 1.

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Psychonautics

Plants That Promise a High and Deliver Nothing: Debunking Myths

A critical review of plants sold as aphrodisiacs, tonics, or cannabis substitutes whose psychoactive effects are nonexistent or imperceptible.
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Psychonautics

What Is Ketamine: Pharmacology, Effects, and Medical Uses

What is ketamine: how it acts on the NMDA receptor, its uses in anesthesia, pain, and depression, and the risks of non-medical use.
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Psychonautics

Ecstasy Cut with Heroin: Anatomy of an Urban Legend

Only three documented reports exist worldwide of heroin in ecstasy pills. We examine the evidence and why heavy sedation stems from MDMA itself.
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Psychonautics

‘LSD: My Problem Child – Albert Hofmann’s Preface’

'LSD: My Problem Child, Albert Hofmann's preface on inner experiences that escape rational explanation and transform our perception of reality.'
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