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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin and Methamphetamine: How Brain Networks Reorganize

Psiconáutica Editorial Team · October 9, 2026 In briefA functional magnetic resonance imaging (fMRI) study compares the brains of people with methamphetamine use disorder before...
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Common Drug Causes False-Positive MDMA Urine Test

Psiconáutica Editorial Team · October 9, 2026 In briefThree patients admitted in Algiers tested positive for MDMA on a rapid urine screen despite no consumption;...
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Psychonautics

Albert Hofmann and Ergot: The Origins of LSD

Albert Hofmann, the lysergic grandfather and pioneering researcher who opened up a new world through his serendipitous discovery, passed away on April 29, 2008, to embark on his final journey—just days after the sixty-fifth anniversary of his famous bicycle ride under the influence of LSD on April 19, 1943, the first acid trip in history.

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Psychonautics

Esketamine (Spravato): The Approved Antidepressant and How It Works

Esketamine (Spravato) is a nasal spray approved for treatment-resistant depression. We explore its NMDA receptor mechanism, evidence, and risks.
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Psychonautics

Escohotado: TV Fame, Trials, and Pharmacological Reason

The biography of Antonio Escohotado, the pioneer of pharmacological enlightenment, continues.

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Psychonautics

Mummies as Drugs: Anatomy of a Psychonautic Hoax

A rumor persists that mummies were consumed for their psychoactive effects. We trace the origin of this hoax: a mistranslation of "drug" as "narcotic" rather than "medicine."
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Psychonautics

Cannabis and Emotions: Learning to Read Your Own Responses

How cannabis might modulate emotional processing, cortisol, and memory, according to psychology, and why these findings should be read with caution.
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