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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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LSD Accelerates Brain Rhythms and Increases Neural Complexity

Psiconáutica Editorial Team · October 8, 2026 In briefA magnetoencephalography (MEG) reanalysis of 17 volunteers indicates that LSD accelerates the brain’s alpha and beta rhythms,...
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Canada Launches New Controlled Substances Regulations for Psilocybin

Psiconáutica Editorial Team · October 8, 2026 In briefOn October 1, 2026, Canada’s new Controlled Substances Regulations went into effect, consolidating several previous rules into...
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Psychonautics

Ann Shulgin and the “Cold Mind”: When the Trip Doesn’t End

We revisit Chapter 38 of PIHKAL, where Ann Shulgin describes a lingering effect, the fear it triggered, and learning not to fight the process.
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Psychonautics

Plants That Promise a High and Deliver Nothing: Debunking Myths

A critical review of plants sold as aphrodisiacs, tonics, or cannabis substitutes whose psychoactive effects are nonexistent or imperceptible.
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News

Market Analysis: How Much Does LSD Cost on the Dark Web?

The unique presentation of LSD makes it a particularly interesting substance on the Dark Web.
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Psychonautics

‘How LSD Originated: Hofmann and the Years Before the Discovery’

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We continue presenting writings by Albert Hofmann. The article that opens this installment recounts the origins of the discovery of LSD. Its title is "How LSD originated"1 and it was published around the date the first German edition of LSD - Mein Sorgenkind was released. Those familiar with Hofmann's autobiographical book will surely find it familiar because it forms part of the material used in writing it.

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Psychonautics

MDMA and Pain Relief: Science, Risk, and Perspective

We explore evidence for the analgesic properties of MDMA, analyzing its serotonergic mechanism, historical clinical cases, and harm reduction.
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