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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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LSD Accelerates Brain Rhythms and Increases Neural Complexity

Psiconáutica Editorial Team · October 8, 2026 In briefA magnetoencephalography (MEG) reanalysis of 17 volunteers indicates that LSD accelerates the brain’s alpha and beta rhythms,...
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Canada Launches New Controlled Substances Regulations for Psilocybin

Psiconáutica Editorial Team · October 8, 2026 In briefOn October 1, 2026, Canada’s new Controlled Substances Regulations went into effect, consolidating several previous rules into...
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Psychonautics

The Risk of a Psychedelic Theocracy: Mysticism vs. Rigorous Science

An analysis of how the obsession with mystical experiences in psychedelic research may be biasing scientific results and limiting progress.
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Psychonautics

Is Getting High Natural? What the Animal Kingdom Teaches Us

Ants, elephants, and humans all seek intoxication. We examine the idea of Siegel’s "fourth drive" and its limits with a critical eye.
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Psychonautics

Ketamine Risks: Cystitis, Dependence, and the K-Hole

Recreational ketamine use is associated with cystitis, kidney damage, dependence, and extreme dissociation (the "K-hole"). Real risks and harm reduction.
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Psychonautics

From Coffee to Ritalin: Stimulants, Childhood, and the ADHD Myth

In this installment, we explore the history of methylphenidate and related substances to gain a broader perspective on what this drug really represents.

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Psychonautics

Ann Shulgin and the “Cold Mind”: When the Trip Doesn’t End

We revisit Chapter 38 of PIHKAL, where Ann Shulgin describes a lingering effect, the fear it triggered, and learning not to fight the process.
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