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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Sustainable Drugophilia: Regulating Drugs Instead of Prohibition

Part three of the series: what sustainable drug use proposes and what legal drug regulation could look like instead of prohibition.
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Psychonautics

Adrenochrome: From Conspiracy Myth to Real Science

What is real about adrenochrome? We separate Illuminati and reptilian myths from the actual psychiatric hypotheses of Abram Hoffer and Humphry Osmond.
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Psychonautics

Cebil and Yopo: The Seeds of Bufotenine

Cebil and yopo contain bufotenine, a visionary entheogen used across South America for millennia. History, tryptamine chemistry, effects, and critical appraisal.
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Psychonautics

Chemsex: Between Clinical Reality and Media Narrative

An analysis of chemsex based on scientific evidence. We distinguish between problematic drug use in sexual contexts and media exaggeration.
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Psychonautics

Salvia divinorum: The Visionary Plant of the Mazatecs

Everything about Salvia divinorum and salvinorin A: traditional Mazatec shamanism, kappa-opioid pharmacology, subjective effects, and harm reduction.
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