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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Regulating Drugs: Sales, Legal Age, and Pricing Models

How would authorized sales, legal age limits, and pricing work in a regulated drug model compared to the chaos of prohibition?
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Psychonautics

Adrenochrome: The Psychedelic Myth vs. Real-World Experiences

User forums and Erowid show adrenochrome causes very mild or negligible effects, far from the myth in Fear and Loathing in Las Vegas.
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Psychonautics

Ketamine Risks: Cystitis, Dependence, and the K-Hole

Recreational ketamine use is associated with cystitis, kidney damage, dependence, and extreme dissociation (the "K-hole"). Real risks and harm reduction.
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Psychonautics

Adrenochrome: The Psychedelic Myth vs. Real-World Experiences

User forums and Erowid show adrenochrome causes very mild or negligible effects, far from the myth in Fear and Loathing in Las Vegas.
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Psychonautics

Ecstasy Cut with Heroin: Anatomy of an Urban Legend

Only three documented reports exist worldwide of heroin in ecstasy pills. We examine the evidence and why heavy sedation stems from MDMA itself.
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