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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...

Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...

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Understanding Iboga: The African Shrub and Ibogaine Alkaloid

Iboga is an African shrub containing ibogaine, an alkaloid studied for addiction treatment that carries significant cardiac risks.

“Hofmann at 100: His Farewell and the Chemistry of Psilocybin”

In this installment, we begin presenting parts of Hofmann’s legacy previously unpublished in Spanish. Available works include LSD: My Problem Child, Insight/Outlook, and a dialogue collection, The Acid God. With Hofmann as coauthor, we also have The Road to Eleusis and Plants of the Gods1.

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Chemsex: Between Clinical Reality and Media Narrative

An analysis of chemsex based on scientific evidence. We distinguish between problematic drug use in sexual contexts and media exaggeration.

Hofmann, Huxley, and Jünger: The Session That Named the Psychonaut

This continues our article "LSD—Completely Personal,"* based on a lecture Albert Hofmann delivered at the 1996 Worlds of Consciousness Conference in Heidelberg, Germany. Hofmann discusses his relationship with Aldous Huxley and begins to recount his encounters with Ernst Jünger, one of the most significant 20th-century German writers and the creator of the term "psychonaut."

LSD, the Medicine of Dr. Albert Hofmann

Aspirin or White Willow? The Truth About Common Painkillers

Who hasn't taken an aspirin? For a headache, the flu, or a common cold, we have all swallowed a pill or sipped an effervescent aspirin at some point. This substance is so everyday and ubiquitous that few know its true name, and almost no one considers it a drug.

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