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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...

Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...

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Drugs and Literature: Creation in Altered States

From romantic opium eaters to the French Decadents and the Beat Generation: how psychoactive substances influenced modern Western literature.

Ibogaine and Addiction: The Evidence Medicine Ignores

Ibogaine, an alkaloid from the African shrub iboga, shows promise against opioid dependence. We review its history, scientific evidence, and real-world risks.

Market Volatility: MDMA Purity and Adulteration in Spain

An analysis of the evolution of MDMA purity in the Spanish illicit market. Historical data, risks of adulteration, and lessons for harm reduction.

Ernst von Bibra and the First Treatises on Psychoactive Substances

After dedicating a series of articles to Albert Hofmann—discoverer of LSD—and three to Antonio Escohotado—author of several books on psychoactive substances, including the monumental and encyclopedic General History of Drugs—we will now look at the pioneers of "drug-philia." We begin with Ernst von Bibra, an author who, by the mid-19th century, was already writing about his experiences with cannabis and other substances known at the time. A pinch of pharmacophilic culture, coming right up!

San Pedro: The Andean Mescaline Cactus

The San Pedro cactus is undoubtedly one of the oldest magical plants in South America, with a history of use spanning over 3,300 years. Known by the botanical name Trichocereus pachanoi, it is a fast-growing, blue-green columnar cactus that can reach heights of up to 20 feet (6 meters), growing at a rate of up to 16 inches (40 cm) per year. Its maximum height is 40 feet (12 meters).

 

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