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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

Psilocybin and Methamphetamine: How Brain Networks Reorganize

Psiconáutica Editorial Team · October 9, 2026 In briefA functional magnetic resonance imaging (fMRI) study compares the brains of people with methamphetamine use disorder before...

Common Drug Causes False-Positive MDMA Urine Test

Psiconáutica Editorial Team · October 9, 2026 In briefThree patients admitted in Algiers tested positive for MDMA on a rapid urine screen despite no consumption;...

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Cannabis and Meditation: Seeking Equanimity

A critical look at the relationship between cannabis, psychedelics, and meditation, focusing on metacognition, equanimity, and harm reduction.

Hofmann and LSD: Chemistry, Potency, and Toxicity

We continue the article begun in our previous installment. Hofmann now describes the properties of the most well-known entheogens of the 1950s—referred to as "psychotomimetics" or "hallucinogens" at the time—among which LSD is counted.

LSD, the medicine of Dr. Albert Hofmann

Coca and Cocaine: A History of Power, Ritual, and Chemistry

 

The coca leaf is obtained from a shrub native to South America, specifically the warm and humid regions of the Andes (Colombia, Bolivia, and Peru). The history of coca plant use is nearly as long as humanity itself. Archaeological remains confirm its consumption in northwestern Peru as early as the sixth millennium BCE.

 

“Where Cannabis Comes From: The Equatorial African Trail”

Every grower of psychoactive cannabis has wondered at some point where the commercial strains grown today actually originate.

Regulating Drugs (Part 5): Demand, Home Cultivation, and Prevention

Part five of our drug regulation model: demand management, home cultivation, consumption spaces, and evidence-based prevention.

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