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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Explore the largest archive on psychoactive substances, published since 1996

LSD Accelerates Brain Rhythms and Increases Neural Complexity

Psiconáutica Editorial Team · October 8, 2026 In briefA magnetoencephalography (MEG) reanalysis of 17 volunteers indicates that LSD accelerates the brain’s alpha and beta rhythms,...

Canada Launches New Controlled Substances Regulations for Psilocybin

Psiconáutica Editorial Team · October 8, 2026 In briefOn October 1, 2026, Canada’s new Controlled Substances Regulations went into effect, consolidating several previous rules into...

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Ibogaine and Addiction: The Evidence Medicine Ignores

Ibogaine, an alkaloid from the African shrub iboga, shows promise against opioid dependence. We review its history, scientific evidence, and real-world risks.

Ecstasy Purity and Adulteration: Spanish Market Data (1985–1995)

A historical analysis of the actual composition of ecstasy in Spain between 1985 and 1995, featuring official laboratory data on purity and adulterants.

Sulbutiamine: The Vitamin B1 Derivative Known as a Nootropic

A large portion of the world’s population uses some form of stimulant. Coffee, tea, mate, cocoa, guarana, coca leaf, ephedra, cocaine, amphetamines... The desire to feel well and experience a positive stimulation that helps us manage daily activities is practically universal.

Cannabis and Psychosis: What the Evidence Says

Can cannabis cause psychosis? We review acute effects, epidemiological data, and the limits of causality with a critical, harm-reduction lens.

Shulgin (II): Mescaline, the DOM Case, and the Solo Path

We continue the biography of Alexander Shulgin, the most important pharmacophile biochemist of our time and a true legend to the global psychonaut community.

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