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Psychedelics Guide

More than 500 articles organized by substance and topic: psilocybin, LSD, ayahuasca, DMT, MDMA, mescaline and harm reduction. Rigorous information, without fear and without propaganda.

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Psilocybin for Persistent Lyme: A 20-Patient Pilot Study

Psiconáutica Editorial Team · October 7, 2026 In briefAn open-label pilot study at Johns Hopkins provided two psilocybin sessions to 20 people with persistent symptoms...
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Delaware Regulates Harm Reduction and Decriminalizes Drug Paraphernalia

Psiconáutica Editorial Team · October 7, 2026 In briefThe Governor of Delaware has signed SB 249, establishing a state licensing system for harm reduction programs.The...
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Psychonautics

Hofmann and Psychotomimetics: A Map of Magic Drugs

In the opening article of this installment, Hofmann explores in greater depth the history, properties, and uses of entheogens.


LSD: Dr. Albert Hofmann's Medicine

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Psychonautics

Mandrake, Lotus, and Lettuce: Psychoactives in Pharaonic Egypt

An ethnobotanical exploration of mandrake, blue lotus, wild lettuce, beer, and wine in ancient Egypt, examining ritual iconographies and historical facts.
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Psychonautics

San Pedro (Trichocereus): Mescaline from Andean Cacti

San Pedro cactus (Trichocereus) contains mescaline. We examine its cultural background, highly variable potency, and why caution is essential.
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Psychonautics

Spanish Fly: Between Historical Legend and Chemical Reality

We debunk the myth of this historical aphrodisiac. We analyze the risks, true toxicity, and the gap between scientific tradition and commercial products.
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Psychonautics

Adrenochrome: The Psychedelic Myth vs. Real-World Experiences

User forums and Erowid show adrenochrome causes very mild or negligible effects, far from the myth in Fear and Loathing in Las Vegas.
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